Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.

@article{Lin2013LossoffunctionAD,
  title={Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.},
  author={Jing-Wen Lin and Patr{\'i}cia Andrade Meireles and Miguel Prud{\^e}ncio and Sabine Engelmann and Takeshi Annoura and Mohammed Sajid and S{\'e}verine Chevalley-Maurel and Jai Ramesar and Carolin Nahar and Cristina M. C. Avramut and Abraham J Koster and Kai Matuschewski and Andrew P Waters and Chris J Janse and Gunnar R Mair and Shahid M Khan},
  journal={Molecular microbiology},
  year={2013},
  volume={88 2},
  pages={318-38}
}
Rhomboid-like proteases cleave membrane-anchored proteins within their transmembrane domains. In apicomplexan parasites substrates include molecules that function in parasite motility and host cell invasion. While two Plasmodium rhomboids, ROM1 and ROM4, have been examined, the roles of the remaining six rhomboids during the malaria parasite's life cycle are unknown. We present systematic gene deletion analyses of all eight Plasmodium rhomboid-like proteins as a means to discover stage-specific… CONTINUE READING