Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice.

@article{Fragkouli2005LossOF,
  title={Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice.},
  author={Apostolia Fragkouli and Catherine Hearn and Mick L. Errington and Sam Cooke and Maria Grigoriou and Tim Bliss and Fotini Stylianopoulou and Vassilis Pachnis},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 11},
  pages={2923-38}
}
The identification of the genetic determinants specifying neuronal networks in the mammalian brain is crucial for the understanding of the molecular and cellular mechanisms that ultimately control cognitive functions. Here we have generated a targeted allele of the LIM-homeodomain-encoding gene Lhx7 by replacing exons 3-5 with a LacZ reporter. In heterozygous animals, which are healthy, fertile and have no apparent cellular deficit in the forebrain, b-galactosidase activity reproduces the… CONTINUE READING
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