• DOI:10.1038/nature09137
Corpus ID: 205221027

Loss of fish actinotrichia proteins and the fin-to-limb transition

@article{Zhang2010LossOF,
  title={Loss of fish actinotrichia proteins and the fin-to-limb transition},
  author={J. Zhang and P. Wagh and D. Guay and L. S{\'a}nchez-Pulido and B. K. Padhi and V. Korzh and M. Andrade-Navarro and M. Akimenko},
  journal={Nature},
  year={2010},
  volume={466},
  pages={234-237}
}

J. Zhang, P. Wagh, +5 authors M. Akimenko

Published 2010

Biology, Medicine

Nature

The early development of teleost paired fins is strikingly similar to that of tetrapod limb buds and is controlled by similar mechanisms. One early morphological divergence between pectoral fins and limbs is in the fate of the apical ectodermal ridge (AER), the distal epidermis that rims the bud. Whereas the AER of tetrapods regresses after specification of the skeletal progenitors, the AER of teleost fishes forms a fold that elongates. Formation of the fin fold is accompanied by the synthesis… CONTINUE READING

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