Loss of fish actinotrichia proteins and the fin-to-limb transition

  title={Loss of fish actinotrichia proteins and the fin-to-limb transition},
  author={J. Zhang and P. Wagh and D. Guay and L. S{\'a}nchez-Pulido and B. K. Padhi and V. Korzh and M. Andrade-Navarro and M. Akimenko},
  • J. Zhang, P. Wagh, +5 authors M. Akimenko
  • Published 2010
  • Biology, Medicine
  • Nature
  • The early development of teleost paired fins is strikingly similar to that of tetrapod limb buds and is controlled by similar mechanisms. One early morphological divergence between pectoral fins and limbs is in the fate of the apical ectodermal ridge (AER), the distal epidermis that rims the bud. Whereas the AER of tetrapods regresses after specification of the skeletal progenitors, the AER of teleost fishes forms a fold that elongates. Formation of the fin fold is accompanied by the synthesis… CONTINUE READING
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