Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.

@article{Gngora2008LossOE,
  title={Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.},
  author={Mar{\'i}a Carolina G{\'o}ngora and Heinrich E. Lob and Ulf Landmesser and Tomasz J. Guzik and William D. Martin and Kiyoski Ozumi and Susan M. Wall and David Scott Wilson and Niren Murthy and Michael B Gravanis and Tohru Fukai and David G Harrison},
  journal={The American journal of pathology},
  year={2008},
  volume={173 4},
  pages={915-26}
}
The extracellular superoxide dismutase 3 (SOD3) is highly expressed in both blood vessels and lungs. In different models of pulmonary injury, SOD3 is reduced; however, it is unclear whether this contributes to lung injury. To study the role of acute SOD3 reduction in lung injury, the SOD3 gene was deleted in adult mice by using the Cre-Lox technology. Acute reduction of SOD3 led to a fivefold increase in lung superoxide, marked inflammatory cell infiltration, a threefold increase in the… CONTINUE READING
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