Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors

@article{Raval2003LossOE,
  title={Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors},
  author={Gira N Raval and Shantaram Bharadwaj and E. A. Levine and Mark C. Willingham and Randolph L. Geary and Tim E Kute and G L Prasad},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={6194-6203}
}
Suppression of tropomyosins (TMs), a family of actin-binding, microfilament-associated proteins, is a prominent feature of many transformed cells. Yet it is unclear whether downregulation of TMs occur in human tumors. We have investigated the expression of tropomyosin-1 (TM1) in human breast carcinoma tissues by in situ hybridization and immunofluorescence. TM1 mRNA and protein are readily detectable in normal mammary tissue. In contrast, TM1 expression is abolished in the primary human breast… CONTINUE READING

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