Loss of expression of the growth inhibitory gene GADD45γ, in human pituitary adenomas, is associated with CpG island methylation

@article{Bahar2004LossOE,
  title={Loss of expression of the growth inhibitory gene GADD45γ, in human pituitary adenomas, is associated with CpG island methylation},
  author={Adil Bahar and John E. Bicknell and David J. W. Simpson and Richard N. Clayton and William E Farrell},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={936-944}
}
Inappropriate expression of cell-cycle regulatory genes and/or their protein products are a frequent finding in pituitary tumours; however, genetic changes associated with or responsible for their dysregulation are in general uncommon. In a search for novel genes, and employing cDNA-representational difference analysis, the gene encoding GADD45γ was recently isolated and identified as being under-represented in pituitary adenomas. GADD45γ is a member of a family of genes that are induced by DNA… CONTINUE READING
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