Loss of expression of DNA mismatch repair proteins in aberrant crypt foci identified in vivo by magnifying colonoscopy in subjects with hereditary nonpolyposic and sporadic colon rectal cancer.

@article{RamrezRamrez2012LossOE,
  title={Loss of expression of DNA mismatch repair proteins in aberrant crypt foci identified in vivo by magnifying colonoscopy in subjects with hereditary nonpolyposic and sporadic colon rectal cancer.},
  author={Miguel Angel Ram{\'i}rez-Ram{\'i}rez and Sergio Roberto Sobrino-Coss{\'i}o and Jos{\'e} Guillermo de la Mora-Levy and Ang{\'e}lica I. Hern{\'a}ndez-Guerrero and Ver{\'o}nica de Jes{\'u}s Macedo-Reyes and H{\'e}ctor Aquiles Maldonado-Mart{\'i}nez and Juan Octavio Alonso-L{\'a}rraga and Mauro Eduardo Ram{\'i}rez-Sol{\'i}s},
  journal={Journal of gastrointestinal cancer},
  year={2012},
  volume={43 2},
  pages={209-14}
}
PURPOSE The aims of this study are to characterize the frequency, density, and distribution of aberrant crypt foci (ACF) and its histological features and to determine the frequency of loss of expression of DNA mismatch repair (MMR) proteins of subjects with hereditary nonpolyposic colorectal cancer (HNPCC) and sporadic colon rectal cancer (CRC). METHODS Patients with HNPCC, first-degree relatives of subjects with HNPCC, sporadic CRC, and average risk subjects of sporadic CRC were included… CONTINUE READING
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