Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1α expression

@article{Giatromanolaki2006LossOE,
  title={Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1α expression},
  author={Alexandra N Giatromanolaki and Michael I. Koukourakis and Efthimios L Sivridis and Kevin C. Gatter and Adrian L. Harris and Alison H Banham},
  journal={Modern Pathology},
  year={2006},
  volume={19},
  pages={9-16}
}
The FOXP1 gene has been identified as a new member of the winged helix family of transcription factors that have important roles in cellular transformation, differentiation and proliferation. In this study, we examined the expression of FOXP1 in the normal and malignant endometrium (stage I endometrioid adenocarcinoma cases), showing a frequent deregulation of its expression in cancer. Proliferative endometrium showed predominantly nuclear localization of FOXP1, while exclusively weak… CONTINUE READING
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Expression of the FOXP 1 transcription factor is strongly associated with inferior survival in patients with diffuse large B - cell lymphoma

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with inferior survival in patients with diffuse large B-cell lymphoma

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