Loss of estrogen receptor beta isoform expression and its correlation with aberrant DNA methylation of the 5'-untranslated region in human epithelial ovarian carcinoma.

@article{Suzuki2008LossOE,
  title={Loss of estrogen receptor beta isoform expression and its correlation with aberrant DNA methylation of the 5'-untranslated region in human epithelial ovarian carcinoma.},
  author={Fumihiko Suzuki and Jun-ichi Akahira and Ikumi Miura and Takashi Suzuki and Kiyoshi Ito and Shin-ichi Hayashi and Hironobu Sasano and Nobuo Yaegashi},
  journal={Cancer science},
  year={2008},
  volume={99 12},
  pages={2365-72}
}
Evidence exists that sex steroids such as estrogens affect epithelial ovarian cancer. The expression profiles of the estrogen receptors (ER) and ERbeta in particular have not been fully described. Therefore, in our present study, we examined the methylation status of the promoters 0K and 0N, and the expression of ERbeta isoforms in human epithelial ovarian carcinoma. We then correlated methylation status with ER expression status. Twelve ovarian carcinoma cell lines, six primary cultures of… CONTINUE READING

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