Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders.

  title={Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders.},
  author={Kristine Roy and Joshua C. Murtie and Bassem F. El-Khodor and Nicole Edgar and S Pablo Sardi and Bryan M Hooks and Marianne Benoit-Marand and Chinfei Chen and Holly Ann Moore and Patricio O'Donnell and Daniela Brunner and Gabriel Corfas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 19},
Several psychiatric disorders are associated with white matter defects, suggesting that oligodendrocyte (OL) abnormalities underlie some aspects of these diseases. Neuregulin 1 (NRG1) and its receptor, erbB4, are genetically linked with susceptibility to schizophrenia and bipolar disorder. In vitro studies suggest that NRG1-erbB signaling is important for OL development. To test whether erbB signaling contributes to psychiatric disorders by regulating the structure or function of OLs, we… CONTINUE READING
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