Loss of epithelial polarity: A novel hypothesis for reduced proximal tubule Na+ transport following ischemic injury

@article{Molitoris1989LossOE,
  title={Loss of epithelial polarity: A novel hypothesis for reduced proximal tubule Na+ transport following ischemic injury},
  author={Bruce A Molitoris and Laurence K. Chan and Joseph Isaac Shapiro and John D. Conger and Sandor A. Falk},
  journal={The Journal of Membrane Biology},
  year={1989},
  volume={107},
  pages={119-127}
}
Ischemia results in the marked reduction of renal proximal tubule function which is manifested by decreased Na+ and H2O reabsorption. In the present studies the possibility that altered Na+ and H2O reabsorption were due to ischemia-induced loss of surface membrane polarity was investigated. Following 15 min of renal ischemia and 2 hr of reperfusion, proximal tubule cellular ultrastructure was normal. However, abnormal redistribution of NaK-ATPase to the apical membrane domain was observed and… CONTINUE READING
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In vivo determinations of absolute molar concentrations of renal phosphorus metabolites using the proton concentration as an internal standard

  • J. I. Shapiro, L. Chan
  • J. Magn. R eson
  • 1987
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