Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema

@article{John2016LossOE,
  title={Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema},
  author={Alison E. John and Michael Wilson and Anthony N Habgood and Joanne Porte and Amanda L Tatler and Anastasios Stavrou and Gino Miele and Lisa Jolly and Alan J. Knox and Masao Takata and Stefan Offermanns and R. Gisli Jenkins},
  journal={Science Signaling},
  year={2016},
  volume={9},
  pages={ra104-ra104}
}
Heterotrimeric guanine nucleotide–binding protein (G protein) signaling links hundreds of G protein–coupled receptors with four G protein signaling pathways. Two of these, one mediated by Gq and G11 (Gq/11) and the other by G12 and G13 (G12/13), are implicated in the force-dependent activation of transforming growth factor–β (TGFβ) in lung epithelial cells. Reduced TGFβ activation in alveolar cells leads to emphysema, whereas enhanced TGFβ activation promotes acute lung injury and idiopathic… CONTINUE READING
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