Loss of epidermal integrity by T cell-mediated attack induces long-term local resistance to subsequent attack. I. Induction of resistance correlates with increases in Thy-1+ epidermal cell numbers

@article{Shiohara1990LossOE,
  title={Loss of epidermal integrity by T cell-mediated attack induces long-term local resistance to subsequent attack. I. Induction of resistance correlates with increases in Thy-1+ epidermal cell numbers},
  author={Tetsuo Shiohara and Nozomu Moriya and C Gotoh and J. -I. Hayakawa and Masakazu Nagashima and K. M. Saizawa and Hiromichi Ishikawa},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={171},
  pages={1027 - 1041}
}
The cutaneous graft-versus-host disease (GVHD) lesions induced by intradermal injection of cloned autoreactive T cells have been shown to subside rapidly and the epidermis returns to normal 2 wk after injection. Those mice that had spontaneously recovered from the cutaneous GVHD became resistant to subsequent attempts to induce the cutaneous GVHD by the T cells while maintaining their activity to mount delayed-type hypersensitivity (DTH) responses and to induce the enlargement of the popliteal… CONTINUE READING
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