Loss of dopaminoreceptive neuron causes L-dopa resistant parkinsonism in tauopathy.

Abstract

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is a family of inherited dementias caused by tauopathy. A mutation in exon 10 of the tau gene, N279K, causes a particular kindred of FTDP-17, which is predominant for parkinsonism. The disease initially presents as L-dopa resistant parkinsonism which then rapidly progresses. The… (More)
DOI: 10.1016/j.neurobiolaging.2011.11.002

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