Loss of dopamine neuron terminals in antipsychotic-treated schizophrenia; relation to tardive dyskinesia

@article{Seeman2013LossOD,
  title={Loss of dopamine neuron terminals in antipsychotic-treated schizophrenia; relation to tardive dyskinesia},
  author={Philip Seeman and Michele Tinazzi},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2013},
  volume={44},
  pages={178-183}
}
The in vivo labeling and brain imaging of dopamine transporters measure the density of dopamine neuron terminals in the human caudate/putamen. A review of such studies shows that the long-term use of antipsychotics had no major effect on the density of the dopamine terminals in individuals who had no tardive dyskinesia, but had reduced the density in those patients with tardive dyskinesia. In addition, the normal loss of dopamine terminals in healthy individuals was approximately 5% per decade… CONTINUE READING

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