Loss of dopamine disrupts circadian rhythms in a mouse model of Parkinson's disease

@article{Fifel2014LossOD,
  title={Loss of dopamine disrupts circadian rhythms in a mouse model of Parkinson's disease},
  author={Karim Fifel and Howard M. Cooper},
  journal={Neurobiology of Disease},
  year={2014},
  volume={71},
  pages={359-369}
}
Although a wide range of physiological functions regulated by dopamine (DA) display circadian variations, the role of DA in the generation and/or modulation of these rhythms is unknown. In Parkinson's disease (PD) patients, in addition to the classical motor symptoms, disturbances of the pattern of daily rest/wake cycles are common non-motor symptoms. We investigated daily and circadian rhythms of rest/activity behaviors in a transgenic MitoPark mouse model with selective inactivation of… CONTINUE READING
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