Loss of dicer exacerbates cyclophosphamide-induced bladder overactivity by enhancing purinergic signaling.

@article{Zhang2012LossOD,
  title={Loss of dicer exacerbates cyclophosphamide-induced bladder overactivity by enhancing purinergic signaling.},
  author={Shuhong Zhang and Jian-wei Lv and Ping Yang and Qilin Yu and Junfeng Pang and Zhihua Wang and Hui Guo and Shenpei Liu and Jia Hu and Jiayi Li and Jin Leng and Yiran Huang and Zhangqun Ye and Congyi Wang},
  journal={The American journal of pathology},
  year={2012},
  volume={181 3},
  pages={937-46}
}
microRNAs (miRNAs) have regulated the expression and function of genes implicated in many pathological settings, but their impact on the pathoetiological characteristics of overactive bladder (OAB) largely remains unknown. We have generated a mouse model in which adult mice can be induced for detrusor deletion of Dicer, an enzyme essential for miRNA processing. Targeted deletion of Dicer did not lead to a significant change for detrusor functionality under physiological conditions; however… CONTINUE READING

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