Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells.

@article{Eshkind2002LossOD,
  title={Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells.},
  author={L. Eshkind and Q. Tian and A. Schmidt and W. Franke and R. Windoffer and R. Leube},
  journal={European journal of cell biology},
  year={2002},
  volume={81 11},
  pages={
          592-8
        }
}
Desmoglein 2 (Dsg2) is a Ca(2+)-dependent adhesion molecule of desmosomes and is synthesized in all desmosome-bearing tissues from their earliest appearance onward. To examine the function of Dsg2, its gene was inactivated by homologous recombination in embryonal stem (ES) cells for the generation of knockout mice. DSG2 -/- mice and a considerable number of DSG2 +/- mice died at or shortly after implantation. On the other hand, DSG2 -/- blastocysts developed an apparently normal trophectoderm… Expand
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