Loss of dendritic spines in aging cerebral cortex

  title={Loss of dendritic spines in aging cerebral cortex},
  author={Martin L. Feldman and Christopher Dowd},
  journal={Anatomy and Embryology},
Previous work has shown that the dendritic spines of pyramidal neurons of the cerebral cortex are sensitive to a wide variety of environmental and surgical manipulations. The present study shows that the normal aging process also affects these spines. The spines were studied with the light microscope in Golgi preparations from rats ranging in age from 3 to 29.5 months. Visible spines were counted on either 25 or 50 μ segments of the basal dendrites, apical dendrites, oblique branches, and… CONTINUE READING
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