Loss of dendritic connectivity in CA1, CA2, and CA3 neurons in hippocampus in rat under aluminum toxicity: Antidotal effect of pyridoxine

@article{Sreekumaran2003LossOD,
  title={Loss of dendritic connectivity in CA1, CA2, and CA3 neurons in hippocampus in rat under aluminum toxicity: Antidotal effect of pyridoxine},
  author={E. Sreekumaran and T. Ramakrishna and T. Madhav and D. Anandh and T. Raju},
  journal={Brain Research Bulletin},
  year={2003},
  volume={59},
  pages={421-427}
}
  • E. Sreekumaran, T. Ramakrishna, +2 authors T. Raju
  • Published 2003
  • Biology, Medicine
  • Brain Research Bulletin
  • Aluminum chloride (AlCl(3); 4 mg/kg) was injected into the cerebrospinal fluid of adult rats as a one time dose. Rapid Golgi stained sections of hippocampus were examined for detailed histology of neurons in CA1, CA2, and CA3 areas. The axonal length and number of dendritic branches were seen reduced 30 days later in aluminum (Al)-injected group when compared to vehicle-injected controls. Of these perturbations, dendritic branches were seen reduced significantly. Al toxicity apparently affects… CONTINUE READING
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    References

    SHOWING 1-10 OF 26 REFERENCES
    Neuronal Development in Vitamin B6 Deficiency
    • 41
    Selective modulation of GABAA receptors by aluminum.
    • P. Trombley
    • Chemistry, Medicine
    • Journal of neurophysiology
    • 1998
    • 30
    • PDF
    The CA1 Region of the Human Hippocampus Is a Hot Spot in Alzheimer's Disease
    • 113
    5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells.
    • 136