Loss of dendritic cell migration and impaired resistance to Leishmania donovani infection in mice deficient in CCL19 and CCL21.

@article{Ato2006LossOD,
  title={Loss of dendritic cell migration and impaired resistance to Leishmania donovani infection in mice deficient in CCL19 and CCL21.},
  author={Manabu Ato and A. Saghai Maroof and Soombul Zubairi and Hideki Nakano and Terutaka Kakiuchi and Paul M. Kaye},
  journal={Journal of immunology},
  year={2006},
  volume={176 9},
  pages={
          5486-93
        }
}
The encounter between APC and T cells is crucial for initiating immune responses to infectious microorganisms. In the spleen, interaction between dendritic cells (DC) and T cells occurs in the periarteriolar lymphoid sheath (PALS) into which DC and T cells migrate from the marginal zone (MZ) along chemokine gradients. However, the importance of DC migration from the MZ into the PALS for immune responses and host resistance to microbial infection has not yet been elucidated. In this study, we… CONTINUE READING

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