Loss of cyclin g1 expression in human uterine leiomyoma cells induces apoptosis.

@article{Kwon2008LossOC,
  title={Loss of cyclin g1 expression in human uterine leiomyoma cells induces apoptosis.},
  author={Sang Hoon Kwon and J H Park and Sabarish Ramachandran and S Cha and Kun Young Kwon and Jong-Ku Park and Jong-Wook Park and Insoo Bae and C -H Cho},
  journal={Reproductive sciences},
  year={2008},
  volume={15 4},
  pages={400-10}
}
Observations from the authors' laboratory suggest a physiological role for increased cyclin G1 protein levels in human uterine leiomyoma. The hypothesis of the present study is that the strategic modulation of cyclin G1 by antisense technology will inhibit the survival of in vitro-grown uterine leiomyoma cells. Cultured uterine leiomyoma cells were transfected with cyclin G1 ribbon-type antisense oligonucleotide (cyclin G1 RiAS) to effectively reduce cyclin G1 expression. Cell viability, in… CONTINUE READING