Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma.

@article{Tsihlias1998LossOC,
  title={Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma.},
  author={J Tsihlias and Linda R Kapusta and Gerrit E Deboer and Isabella Morava-Protzner and I Zbieranowski and Nandita Bhattacharya and G. C. Catzavelos and Laurence H. Klotz and Joyce M Slingerland},
  journal={Cancer research},
  year={1998},
  volume={58 3},
  pages={542-8}
}
p27Kip1 is a cyclin-dependent kinase inhibitor that negatively regulates cell proliferation by mediating cell cycle arrest in G1. This study was undertaken to assess the prognostic value of p27Kip1 in localized human prostate cancer. Archival material from 113 radical prostatectomy specimens obtained between 1985 and 1993 was stained immunohistochemically for p27Kip1 protein using a commercially available antibody. Patient charts were reviewed for preoperative serum prostate-specific antigen… CONTINUE READING
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