Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.

@article{Zhao2012LossOC,
  title={Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.},
  author={Hui Zhao and Xueyan Chen and Mark Gurian-West and James M Roberts},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 8},
  pages={1421-32}
}
Cyclin-dependent kinase 1 (CDK1) inhibitory phosphorylation controls the onset of mitosis and is essential for the checkpoint pathways that prevent the G(2)- to M-phase transition in cells with unreplicated or damaged DNA. To address whether CDK2 inhibitory phosphorylation plays a similar role in cell cycle regulation and checkpoint responses at the start of the S phase, we constructed a mouse strain in which the two CDK2 inhibitory phosphorylation sites, threonine 14 and tyrosine 15, were… CONTINUE READING

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A roller coaster ride with the mitotic cyclins.

Seminars in cell & developmental biology • 2005
View 6 Excerpts
Highly Influenced

Cyclin E Ablation in the Mouse

Cell • 2003
View 5 Excerpts
Highly Influenced

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