Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma.


PURPOSE Many solid tumors exhibit abnormal aerobic metabolism characterized by increased glycolytic capacity and decreased cellular respiration. Recently, mutations in the nuclear encoded mitochondrial enzymes fumarate hydratase and succinate dehydrogenase have been identified in certain tumor types, thus demonstrating a direct link between mitochondrial… (More)
DOI: 10.1158/1078-0432.CCR-07-4131


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