Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease.

@article{Gross2010LossOC,
  title={Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease.},
  author={Oliver A. Gross and Rainer Girgert and Bogdan Beirowski and Matthias Kretzler and Hee Gyung Kang and Jenny Kruegel and Nicolai Miosge and A Busse and Stephan Segerer and Wolfgang F. Vogel and Gerhard A. M{\"u}ller and Manfred Weber},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2010},
  volume={29 5},
  pages={346-56}
}
Alport syndrome is a hereditary type IV collagen disease leading to progressive renal fibrosis, hearing loss and ocular changes. End stage renal failure usually develops during adolescence. COL4A3-/- mice serve as an animal model for progressive renal scarring in Alport syndrome. The present study evaluates the role of Discoidin Domain Receptor 1 (DDR1) in cell-matrix interaction involved in pathogenesis of Alport syndrome including renal inflammation and fibrosis. DDR1/COL4A3 Double-knockouts… CONTINUE READING

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