Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease.

@article{McAleese2001LossOC,
  title={Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease.},
  author={Fionnuala M McAleese and Evelyn J. Walsh and M Sieprawska and Jan Potempa and T. J. Foster},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 32},
  pages={29969-78}
}
The fibrinogen-binding protein clumping factor B (ClfB) of Staphylococcus aureus is present on the surface of cells from the early exponential phase of growth in greater amounts than on cells from late exponential phase and is barely detectable on cells from stationary phase. Expression of a clfB-lacZ fusion indicated that transcription stopped before the end of exponential phase. Mutations in the global regulators agr and sar had no effect on clfB transcription. The loss of ClfB protein from… CONTINUE READING
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