Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine.

@article{Tamura2011LossOC,
  title={Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine.},
  author={Atsushi Tamura and Hisayoshi Hayashi and Mitsunobu Imasato and Yuji Yamazaki and Asuka Hagiwara and Masami Wada and Tetsuo Noda and Mitsuhiro Watanabe and Yuichi Suzuki and Sachiko Tsukita},
  journal={Gastroenterology},
  year={2011},
  volume={140 3},
  pages={913-23}
}
BACKGROUND & AIMS In the small intestine, the paracellular transport of Na(+) is thought to be critical for luminal Na(+)-homeostasis and the transcellular absorption of nutrients by Na(+)-driven transporters. Na(+) is supplied to the intestinal lumen from the submucosa and serum through tight junctions, which form a paracellular barrier between the cells of epithelial sheets. However, the molecular basis for this paracellular transport of Na(+) is not well understood. Here, we examined this… CONTINUE READING

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