Loss of classical transient receptor potential 6 channel reduces allergic airway response.

@article{Sel2008LossOC,
  title={Loss of classical transient receptor potential 6 channel reduces allergic airway response.},
  author={Serdar Sel and Benjamin Rainer Rost and Ali Oender Yildirim and B. Dikcinar Sel and Hermann Kalwa and Heinz Fehrenbach and Harald Renz and Thomas Gudermann and Alexander Dietrich},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2008},
  volume={38 9},
  pages={1548-58}
}
BACKGROUND Non-selective cation influx through canonical transient receptor potential channels (TRPCs) is thought to be an important event leading to airway inflammation. TRPC6 is highly expressed in the lung, but its role in allergic processes is still poorly understood. OBJECTIVE The purpose of this study was to evaluate the role of TRPC6 in airway hyperresponsiveness (AHR) and allergic inflammation of the lung. METHODS Methacholine-induced AHR was assessed by head-out body… CONTINUE READING