Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

@inproceedings{Ma2013LossOC,
  title={Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease},
  author={Ming Ma and Xin Tian and Peter Igarashi and Gregory J Pazour and Stefan Somlo},
  booktitle={Nature Genetics},
  year={2013}
}
Kidney cysts occur following inactivation of polycystins in otherwise intact cilia or following complete removal of cilia by inactivation of intraflagellar transport–related proteins. We investigated the mechanisms of cyst formation in these two distinct processes by combining conditional inactivation of polycystins with concomitant ablation of cilia in developing and adult kidney and liver. We found that loss of intact cilia suppressed cyst growth following inactivation of polycystins and that… CONTINUE READING