Loss of cell wall alpha(1-3) glucan affects Cryptococcus neoformans from ultrastructure to virulence.

@article{Reese2007LossOC,
  title={Loss of cell wall alpha(1-3) glucan affects Cryptococcus neoformans from ultrastructure to virulence.},
  author={Amy J Reese and Aki Yoneda and Julia A Breger and Anne Beauvais and Hong Liu and Cara L Griffith and Indrani Bose and M Y Kim and Colleen T. Skau and Sarah S Yang and Julianne A. Sefko and Masako Osumi and J. P. Latg{\'e} and Eleftherios Mylonakis and Tamara L Doering},
  journal={Molecular microbiology},
  year={2007},
  volume={63 5},
  pages={1385-98}
}
Yeast cell walls are critical for maintaining cell integrity, particularly in the face of challenges such as growth in mammalian hosts. The pathogenic fungus Cryptococcus neoformans additionally anchors its polysaccharide capsule to the cell surface via alpha(1-3) glucan in the wall. Cryptococcal cells disrupted in their alpha glucan synthase gene were sensitive to stresses, including temperature, and showed difficulty dividing. These cells lacked surface capsule, although they continued to… CONTINUE READING

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