Loss of cell cycle regulators p27(Kip1) and cyclin E in transitional cell carcinoma of the bladder correlates with tumor grade and patient survival.

@article{Pizzo1999LossOC,
  title={Loss of cell cycle regulators p27(Kip1) and cyclin E in transitional cell carcinoma of the bladder correlates with tumor grade and patient survival.},
  author={Joseph J. Del Pizzo and Andrew A. Borkowski and Stephen C Jacobs and Natasha Kyprianou},
  journal={The American journal of pathology},
  year={1999},
  volume={155 4},
  pages={1129-36}
}
The cyclin-dependent kinase inhibitor p27(Kip1) is a powerful molecular determinant of cell cycle progression. Loss of expression of p27(Kip1) has been shown to be predictive of disease progression in several human malignancies. In this study we investigated the expression of two key cell cycle regulators, p27(Kip1) and cyclin E, in the progression of transitional cell carcinoma of the bladder. An immunohistochemical analysis was conducted in a series of 50 bladder tumor specimens, including 3… CONTINUE READING

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