Loss of caveolin-3 induced by the dystrophy-associated P104L mutation impairs L-type calcium channel function in mouse skeletal muscle cells.

@article{Couchoux2007LossOC,
  title={Loss of caveolin-3 induced by the dystrophy-associated P104L mutation impairs L-type calcium channel function in mouse skeletal muscle cells.},
  author={Harold Couchoux and Bruno Allard and Claude Legrand and Vincent Jacquemond and Christine Berthier},
  journal={The Journal of physiology},
  year={2007},
  volume={580 Pt.3},
  pages={745-54}
}
Caveolins are membrane scaffolding proteins that associate with and regulate a variety of signalling proteins, including ion channels. A deficiency in caveolin-3 (Cav-3), the major striated muscle isoform, is responsible for skeletal muscle disorders, such as limb-girdle muscular dystrophy 1C (LGMD 1C). The molecular mechanisms leading to the muscle wasting that characterizes this pathology are poorly understood. Here we show that a loss of Cav-3 induced by the expression of the LGMD 1C… CONTINUE READING

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