Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice.

@article{Williams2003LossOC,
  title={Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice.},
  author={Terence M. Williams and Michelle W-C Cheung and David S. Park and Babak Razani and Alex W. Cohen and William J. Muller and Dolores Di Vizio and Neeru G Chopra and Richard G. Pestell and Michael Phillip Lisanti},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 3},
  pages={
          1027-42
        }
}
Caveolin-1 is the principal structural component of caveolae microdomains, which represent a subcompartment of the plasma membrane. Several independent lines of evidence support the notion that caveolin-1 functions as a suppressor of cell transformation. For example, the human CAV-1 gene maps to a suspected tumor suppressor locus (D7S522/7q31.1) that is frequently deleted in a number of carcinomas, including breast cancers. In addition, up to 16% of human breast cancers harbor a dominant… CONTINUE READING

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