Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons.

@article{Tiwari2011LossOC,
  title={Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons.},
  author={Meenakshi Tiwari and Marisa Lopez-Cruzan and William W. Morgan and Bryan K. Herman},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 10},
  pages={
          8493-506
        }
}
Mitochondrial dysfunctions have been associated with neuronal apoptosis and are characteristic of neurodegenerative conditions. Caspases play a central role in apoptosis; however, their involvement in mitochondrial dysfunction-induced neuronal apoptosis remains elusive. In the present report using rotenone, a complex I inhibitor that causes mitochondrial dysfunction, we determined the initiator caspase and its role in cell death in primary cultures of cortical neurons from young adult mice (1-2… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 42 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-2 OF 2 REFERENCES

Caspase-2 in Neuronal Mitochondrial Stress-induced Apoptosis

  • C. M. Troy, S. A. Rabacchi, J. B. Hohl, J. M. Angelastro, L. A. Greene
  • MARCH 11,
  • 2011
2 Excerpts

Caspase-2 in Neuronal Mitochondrial Stress-induced Apoptosis 8506 JOURNAL OF BIOLOGICAL CHEMISTRY

  • T. Kuwana, D. D. Newmeyer
  • Curr. Opin. Cell Biol
  • 2003
1 Excerpt

Similar Papers

Loading similar papers…