Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy.

@article{Pereyra2017LossOC,
  title={Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy.},
  author={Andrea S Pereyra and Like Y Hasek and Kate L Harris and Alycia G. Berman and Frederick W. Damen and Craig J. Goergen and Jessica M Ellis},
  journal={The Journal of biological chemistry},
  year={2017},
  volume={292 45},
  pages={18443-18456}
}
Cardiac hypertrophy is closely linked to impaired fatty acid oxidation, but the molecular basis of this link is unclear. Here, we investigated the loss of an obligate enzyme in mitochondrial long-chain fatty acid oxidation, carnitine palmitoyltransferase 2 (CPT2), on muscle and heart structure, function, and molecular signatures in a muscle- and heart-specific CPT2-deficient mouse (Cpt2M-/-) model. CPT2 loss in heart and muscle reduced complete oxidation of long-chain fatty acids by 87 and 69… CONTINUE READING