Loss of calcium in human spermatozoa via EPPIN, the semenogelin receptor.

@article{ORand2012LossOC,
  title={Loss of calcium in human spermatozoa via EPPIN, the semenogelin receptor.},
  author={Michael G O'Rand and Esther E. Widgren},
  journal={Biology of reproduction},
  year={2012},
  volume={86 2},
  pages={55}
}
The development of a new male contraceptive requires a transition from animal model to human and an understanding of the mechanisms involved in the target's inhibition of human spermatozoan fertility. We now report that semenogelin (SEMG1) and anti-EPPIN antibodies to a defined target site of 21 amino acids on the C terminal of EPPIN cause the loss of intracellular calcium, as measured by Fluo-4. The loss of intracellular calcium explains our previous observations of an initial loss of… CONTINUE READING