Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice.

@article{Enwere2013LossOC,
  title={Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice.},
  author={Emeka K. Enwere and Louise Boudreault and Janelle Holbrook and Kristen Timusk and Nathalie Earl and Eric Charles LaCasse and J C Renaud and R. G. Korneluk},
  journal={Human molecular genetics},
  year={2013},
  volume={22 5},
  pages={867-78}
}
The cellular inhibitor of apoptosis 1 (cIAP1) protein is an essential regulator of canonical and noncanonical nuclear factor κB (NF-κB) signaling pathways. NF-κB signaling is known to play important roles in myogenesis and degenerative muscle disorders such as Duchenne muscular dystrophy (DMD), but the involvement of cIAP1 in muscle disease has not been studied directly. Here, we asked whether the loss of cIAP1 would influence the pathology of skeletal muscle in the mdx mouse model of DMD… CONTINUE READING

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