Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice.

@article{Liebl2000LossOB,
  title={Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice.},
  author={Daniel J. Liebl and Laura J Klesse and Lino Tessarollo and T Wohlman and Luis F. Parada},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 5},
  pages={2297-302}
}
Peripheral ganglion neurons confer sensory information including touch, pain, temperature, and proprioception. Sensory modality is linked to specific neurotrophin (NTF) requirements. NT-3 supports survival of neurons that differentiate primarily into proprioceptors whereas nerve growth factor and brain-derived neurotrophic factor (BDNF) support subpopulations that transmit nociception and mechanoreception, respectively. We examined sensory neurons of gene-targeted mouse mutants at the NT-4… CONTINUE READING

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