Loss of bradykinin receptors and TPA-stimulated Na+ influx in SV40-transformed WI-38 cells.

@article{Etscheid1990LossOB,
  title={Loss of bradykinin receptors and TPA-stimulated Na+ influx in SV40-transformed WI-38 cells.},
  author={B G Etscheid and Graham A Jamieson and K Toscas and Mitchel L Villereal},
  journal={The American journal of physiology},
  year={1990},
  volume={259 4 Pt 1},
  pages={C549-56}
}
Mitogenic stimulation of Na(+)-H+ exchange activity, as defined by the level of 5-(N,N-hexamethylene)amiloride (HMA)-sensitive Na+ influx, was compared in WI-38 and SV40 virus-transformed WI-38 fibroblasts. Serum or bradykinin dramatically stimulated HMA-sensitive Na+ influx in WI-38 cells, whereas in SV40-transformed WI-38 cells, serum, but not bradykinin, produced a large increase in HMA-sensitive Na+ influx. This lack of a bradykinin response was traced to a dramatic reduction in the number… CONTINUE READING