Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization.

@article{Holm2015LossOB,
  title={Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization.},
  author={Erik Jonsson Holm and Jane E. Aubin and Graeme K. Hunter and Frank M. Beier and Harvey A. Goldberg},
  journal={Bone},
  year={2015},
  volume={71},
  pages={145-54}
}
Bone sialoprotein (BSP) is an anionic phosphoprotein in the extracellular matrix of mineralized tissues, and a promoter of biomineralization and osteoblast development. Previous studies on the Bsp-deficient mouse (Bsp(-/-)) have demonstrated a significant bone and periodontal tissue phenotype in adulthood. However, the role of BSP during early long bone development is not known. To address this, early endochondral ossification in the Bsp(-/-) mouse was studied. Embryonic day 15.5 (E15.5) wild… CONTINUE READING
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during endochondral bone growth

  • V Ulici, KD Hoenselaar, H Agoston, DD McErlain, J Umoh, S Chakrabarti
  • 2012

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