Loss of axons in the cat optic nerve following fetal unilateral enucleation: an electron microscopic analysis.

@article{Williams1983LossOA,
  title={Loss of axons in the cat optic nerve following fetal unilateral enucleation: an electron microscopic analysis.},
  author={R. W. Williams and Michael J. Bastiani and Leo M. Chalupa},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1983},
  volume={3 1},
  pages={133-44}
}
Between the 48th day of gestation (E-48) and maturity, the number of axons in the cat optic nerve is reduced by approximately 50%. On the basis of an electron microscopic assay, the axon population of the E-48 nerve was estimated to be 328,000. In contrast, estimates from two normal adults were 159,000 and 158,000. In utero unilateral enucleation (at E-45 and E-46) attenuated the severity of this loss since the optic nerves of the experimental animals contained 200,000 and 198,000 fibers. These… CONTINUE READING
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