Loss of autoreceptor functions in mice lacking the dopamine transporter

  title={Loss of autoreceptor functions in mice lacking the dopamine transporter},
  author={S. Jones and R. Gainetdinov and Xiu-Ti Hu and D. Cooper and R. Wightman and F. White and M. Caron},
  journal={Nature Neuroscience},
  • S. Jones, R. Gainetdinov, +4 authors M. Caron
  • Published 1999
  • Medicine, Biology
  • Nature Neuroscience
  • Autoreceptors provide an important inhibitory feedback mechanism for dopamine neurons by altering neuronal functions in response to changes in extracellular levels of dopamine. Elevated dopamine may be a component of several neuropsychiatric disorders. However, evidence concerning the state of autoreceptors in such conditions has remained elusive. The function of dopamine autoreceptors was assessed in mice lacking the dopamine transporter (DAT). Genetic deletion of the DAT gene in mice results… CONTINUE READING

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