Loss of auditory function in transgenic Mpv17-deficient mice

@article{Mller1997LossOA,
  title={Loss of auditory function in transgenic Mpv17-deficient mice},
  author={Marcus M{\"u}ller and Joost Smolders and A. Meyer zum Gottesberge and Alexander Reuter and Rainer Klinke},
  journal={Hearing Research},
  year={1997},
  volume={114},
  pages={259-263}
}
The transgenic mouse strain Mpv17 develops severe morphological degeneration of the inner ear and nephrotic syndrome at a young age (Meyer zum Gottesberge et al., 1996; Weiher et al., 1990). The audiograms (1-32 kHz) of Mpv17-negative mice were determined from auditory brain stem responses in young (2 months) and old (7 months) animals. Audiograms of age-matched wild-type mice with the same genetic background, but wild-type at the Mpv17 locus, were also determined. Furthermore, young Mpv17… CONTINUE READING
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