Loss of attachment to fibronectin with terminal human erythroid differentiation.

@article{VuilletGaugler1990LossOA,
  title={Loss of attachment to fibronectin with terminal human erythroid differentiation.},
  author={M H Vuillet-Gaugler and Janine Breton-Gorius and William Vainchenker and Josette Guichard and Catherine Leroy and Gil Tchernia and Laure Coulombel},
  journal={Blood},
  year={1990},
  volume={75 4},
  pages={865-73}
}
Human erythroblastic progenitors (colony-forming unit-erythroid [CFU-E] and burst-forming unit-erythroid [BFU-E]) have been shown to attach to fibronectin (Fn), a property that might be involved in the local regulation of erythropoiesis. In this study, we have investigated changes in cell attachment to Fn upon terminal erythroid differentiation. We first purified CFU-E from human marrow by avidin-biotin immune rosetting. This negative selection procedure yielded a cell population containing… CONTINUE READING