Loss of asymmetric spine synapses in dorsolateral prefrontal cortex of cognitively impaired phencyclidine-treated monkeys.

@article{Elsworth2011LossOA,
  title={Loss of asymmetric spine synapses in dorsolateral prefrontal cortex of cognitively impaired phencyclidine-treated monkeys.},
  author={John D. Elsworth and Tibor Hajszan and Csaba L{\'e}r{\'a}nth and Robert H. Roth},
  journal={The international journal of neuropsychopharmacology},
  year={2011},
  volume={14 10},
  pages={1411-5}
}
Schizophrenia patients, long-term abusers of phencyclidine (PCP), and monkeys treated with PCP all exhibit enduring cognitive deficits. Evidence indicates that loss of prefrontal cortex spine synapses results in cognitive dysfunction, suggesting the presence of synaptic pathology in the monkey PCP model; however, there is no direct evidence of such changes. In this study we use the monkey PCP model of schizophrenia to investigate at the ultrastructural level whether remodelling of dorsolateral… CONTINUE READING