Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice

@article{Niu2008LossOA,
  title={Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice},
  author={M Niu and Jinkui Yang and Shan-Shan Lin and Xiu-Juan Ji and Li-min Guo},
  journal={Endocrine},
  year={2008},
  volume={34},
  pages={56-61}
}
This study aimed to investigate the role of angiotensin-converting enzyme 2 (ACE2) in regulating glucose homeostasis. Immunohistochemistry was used to investigate ACE2 expression in the pancreas. Glucose tolerance test, insulin secretion test, and insulin tolerance test were performed in age-matched male ACE2 knockout (KO) and wild-type (WT) mice. We found that ACE2 was positively expressed in the pancreas. Male ACE2 KO mice displayed a selective decrease in first-phase insulin secretion in… CONTINUE READING

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