Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis.

@article{Patel2012LossOA,
  title={Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis.},
  author={Vaibhav B Patel and Sreedhar Bodiga and Ratnadeep Basu and Subhash K. Das and Wang Wang and Zuocheng Wang and Jennifer Lo and Maria B Grant and Jiuchang Zhong and Zamaneh Kassiri and Gavin Y Oudit},
  journal={Circulation research},
  year={2012},
  volume={110 10},
  pages={
          1322-35
        }
}
RATIONALE Diabetic cardiovascular complications are reaching epidemic proportions. Angiotensin-converting enzyme-2 (ACE2) is a negative regulator of the renin-angiotensin system. We hypothesize that loss of ACE2 exacerbates cardiovascular complications induced by diabetes. OBJECTIVE To define the role of ACE2 in diabetic cardiovascular complications. METHODS AND RESULTS We used the well-validated Akita mice, a model of human diabetes, and generated double-mutant mice using the ACE2 knockout… CONTINUE READING

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