Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota

@article{Janssen2018LossOA,
  title={Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota},
  author={Aafke W. F. Janssen and Saeed Katiraei and Barbara Bartosinska and Daniel Eberhard and Ko Willems van Dijk and Sander Kersten},
  journal={Diabetologia},
  year={2018},
  volume={61},
  pages={1447-1458}
}
Angiopoietin-like 4 (ANGPTL4) is an important regulator of triacylglycerol metabolism, carrying out this role by inhibiting the enzymes lipoprotein lipase and pancreatic lipase. ANGPTL4 is a potential target for ameliorating cardiometabolic diseases. Although ANGPTL4 has been implicated in obesity, the study of the direct role of ANGPTL4 in diet-induced obesity and related metabolic dysfunction is hampered by the massive acute-phase response and development of lethal chylous ascites and… CONTINUE READING
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