Loss of anchorage in checkpoint-deficient cells increases genomic instability and promotes oncogenic transformation.

@article{Cremona2009LossOA,
  title={Loss of anchorage in checkpoint-deficient cells increases genomic instability and promotes oncogenic transformation.},
  author={Catherine A. Cremona and Alison C. Lloyd},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 18},
  pages={3272-81}
}
Mammalian cells generally require both mitogens and anchorage signals in order to proliferate. An important characteristic of many tumour cells is that they have lost this anchorage-dependent cell-cycle checkpoint, allowing them to proliferate without signals provided by their normal microenvironment. In the absence of anchorage signals from the extracellular matrix, many cell types arrest cell-cycle progression in G1 phase as a result of Rb-dependent checkpoints. However, despite inactivation… CONTINUE READING